wp-admin/options.php in WordPress MU before 1.3.2, and WordPress 2.3.2 and earlier, does not properly validate requests to update an option, which allows remote authenticated users with manage_options and upload_files capabilities to execute arbitrary code by uploading a PHP script and adding this script's pathname to active_plugins.
http://www.securityfocus.com/bid/27633
http://securityreason.com/securityalert/4798
http://secunia.com/advisories/28789
http://mu.wordpress.org/forums/topic.php?id=7534&page&replies=1