Python-RSA before 4.1 ignores leading '\0' bytes during decryption of ciphertext. This could conceivably have a security-relevant impact, e.g., by helping an attacker to infer that an application uses Python-RSA, or if the length of accepted ciphertext affects application behavior (such as by causing excessive memory allocation).
https://usn.ubuntu.com/4478-1/
https://github.com/sybrenstuvel/python-rsa/issues/146#issuecomment-641845667