Substance3D - Sampler versions 4.5 and earlier are affected by a NULL Pointer Dereference vulnerability that could lead to an application denial-of-service (DoS) condition. An attacker could exploit this vulnerability to crash the application, resulting in a DoS. Exploitation of this issue requires user interaction in that a victim must open a malicious file.
https://helpx.adobe.com/security/products/substance3d-sampler/apsb24-65.html